Pharmacotherapy of Basal Cell Carcinoma, Anogenital Warts, and Actinic Keratoses: Focus on Topical Imiquimod
نویسندگان
چکیده
Imiquimod, an imidazoquinoline compound, has been widely-recognized for its ability to induce both innate and adaptive immune responses. Topical imiquimod has been approved for the treatment of actinic keratoses (AK), external genital warts (EGW), and superficial basal cell carcinoma (BCC). There are reports of many successful off-label uses as well. The pharmacology and mechanisms of action, safety, efficacy, and adverse effects with regards to differing concentrations and dosing regimens are discussed in depth in this chapter. Field-directed therapies for AK along with non-surgical treatments for BCC are rapidly-evolving, with increasing numbers of studies providing evidence-based rationale for their use in management.
منابع مشابه
Safety, efficacy, and patient acceptability of imiquimod for topical treatment of actinic keratoses
Imiquimod, an immune-modulating imidazoquinoline compound, has been approved in topical formulation for the treatment of actinic keratoses, superficial basal cell carcinomas, and external genital warts. Its use in the treatment of field cancerization, in particular, has been rapidly evolving. With the recent approval of a new drug application for a new concentration, as well as generic formulat...
متن کاملVisualization and Treatment of Subclinical Actinic Keratoses with Topical Imiquimod 5% Cream: An Observational Study
BACKGROUND Imiquimod 5% is licensed for the treatment of external genital warts, superficial basal cell carcinoma, and actinic keratosis (AK) and is being used experimentally in various other dermato-oncological conditions. OBJECTIVE This observational study shall show that nonmelanoma skin cancer can be detected at its earliest subclinical stage by its reaction with imiquimod and can be clea...
متن کاملDisseminated porokeratosis palmaris and plantaris treated with imiquimod cream to prevent malignancy.
Sir, Disseminated porokeratosis palmaris and plantaris (DPPP), a subtype of porokeratosis Mibelli, is a rare autosomal dominant genodermatosis first described by Guss et al. in 1971 (1). An early review of the literature showed that 7% of 250 patients with porokeratosis subsequently developed skin tumours (2). Squamous cell carcinomas (SCC), Bowen’s disease (BD), and rarely, basal cell carcinom...
متن کامل[Erythema multiforme due to 5% imiquimod cream].
Imiquimod 5% cream (Aldara, 3M Pharmaceuticals) is a topical immunomodulator approved for the treatment of genital warts, actinic keratoses, and superficial basal cell carcinoma, although it is also used off-label in clinical practice for other dermatologic conditions. Although local side effects are most frequent, it can also produce systemic side effects. We describe the case of a patient who...
متن کاملTopical therapy for actinic keratoses: current and evolving therapies.
Actinic keratoses (AKs) are evolving malignant cutaneous neoplasms. They are also known as solar keratosis, squamous cell carcinoma in situ-solar keratotic type, or keratinocytic intraepidermal neoplasia. Actinic keratoses can be treated by two general methods: by physical/destructive methods and with topical therapies. This article will review current and evolving topical therapeutic options f...
متن کامل